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What Is Metformin?

Metformin is an oral medication primarily prescribed to help manage blood sugar levels in people with various diabetic conditions such as Type 2 diabetes. The drug even works as a preventative measure for people with prediabetes, a condition where blood sugar levels are higher than normal but not high enough to be diagnosed with type 2 diabetes. However, in certain instances, physicians can also use the medicine off-label to treat and manage other health conditions, such as polycystic ovarian syndrome and even weight gain in overweight and obese patients.

How Does Metformin Work for Weight Loss?

Step
Reduces Intestinal Glucose Absorption

Metformin reduces how much sugar the intestines absorb from food consumption after you eat, thus lowering the amount of glucose that travels through the bloodstream.

Step
Decreases Hepatic Glucose Production

Metformin decreases the amount of sugar that the liver produces on its own, effectively lowering the sugar production that naturally occurs in the body.

Step
Improves Insulin Sensitivity

Metformin reduces insulin resistance and improves insulin sensitivity, allowing your cells to effectively utilize sugars from the foods you consume. This helps to break down calories into energy more effectively, maintaining lower blood sugar levels after every meal consistently.

Before & After

Donna J.

I am 67 years old and pleased to admit that along with being on therapy with [Slim Clinic], I exercise 2x weekly with 1 hour functional training sessions, then 30-45 minutes 3-4 days per week on a Pelaton. I couldn't be happier with the results.

Before: 165 lbs // After: 130 lbs

I am 67 years old and pleased to admit that along with being on therapy with [Slim Clinic], I exercise 2x weekly with 1 hour functional training sessions, then 30-45 minutes 3-4 days per week on a Pelaton. I couldn't be happier with the results.

Before: 165 lbs // After: 130 lbs

Donna J.

I am 67 years old and pleased to admit that along with being on therapy with [Slim Clinic], I exercise 2x weekly with 1 hour functional training sessions, then 30-45 minutes 3-4 days per week on a Pelaton. I couldn't be happier with the results.

Before: 165 lbs // After: 130 lbs

Metformin
Timeframe
6 Months
Results
Lost 35lbs
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Does Metformin Cause Weight Loss?

Although metformin is not approved for weight loss, studies show that its effects on glucose can help patients lose weight during treatment. There are various theories on how metformin causes weight loss, but the most common ways include:

Appetite Reduction

Metformin increases insulin sensitivity and improves the body’s response to leptin, a hormone that regulates hunger by stimulating feelings of fullness. It may also increase the release of the GLP-1 hormone, which suppresses appetite. This combination helps inhibit food cravings and control appetite, making it easier to avoid excessive calorie intake.

Promoting Insulin Sensitivity

Metformin increases insulin receptor activity, activating pathways that transport insulin from the pancreas to where it is needed. This regulation of blood glucose levels allows for effective sugar movement through the bloodstream to be used as energy, especially in muscle tissue, reducing blood sugar levels.

Changing Your Gut Microbiome

Metformin alters the gut microbiome, which contains microorganisms that support digestion and energy utilization from food. These microbes help break down distinct molecules from meats and vegetables, manage food cravings, and provide a feeling of fullness after digestion. By optimizing the microbiome, metformin promotes a healthy gut balance, effective digestion, and potentially stimulates weight loss

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How To Take

Can I Take Metformin for Weight Loss Without Having Diabetes?

Yes. Although metformin is not approved as a weight loss drug, it can be used as an off-label treatment to assist in weight loss for people without diabetes. In fact, many physicians commonly prescribe metformin first as a weight loss treatment for obese patients struggling to lose weight.

What Is the Correct Dosage for Weight Loss in Non Diabetics

Since metformin is used off-label for weight loss when treating weight-related conditions such as obesity, there isn’t necessarily a correct or proper dosage regarding using the medication as a weight loss treatment in non-diabetics. In these instances, a physician will typically study your medical history to determine what may be the best metformin dosage for your body to help you achieve your weight-loss goals. More often than not, many physicians will prescribe a low dose of metformin at the beginning of treatment to allow your body time to adjust to the medication before slowly increasing the dosage over the following weeks.

Can You Take Metformin and Ozempic Together?

Yes. Metformin and Ozempic are generally safe to use together. In fact, many physicians commonly integrate the two medications into a combination therapy to help manage blood sugar levels, assist in cardiovascular health, and of course, promote weight loss. However, taking metformin and Ozempic together can also increase the risk of certain gastrointestinal side effects such as nausea, vomiting, and diarrhea, so always discuss these potential issues with your doctor before combining the two medications as part of your treatment.

How Much Weight Can You Lose on Metformin?

The amount of weight you’ll lose on metformin will depend on your current weight, your medical history, and your body’s response to medication. However, in a 2013 study published in the National Library of Medicine, research revealed that overweight patients with a body mass index (BMI) less than 27 experienced 5% to 6% weight loss after six months of treatment with metformin.

The speed at which metformin helps you lose weight also depends on your body’s response to the medication. Based on the study previously mentioned, patients can expect to see significant weight loss results after 28 weeks with metformin, as long as they combine the medicine with a balanced diet and regular exercise

How Slim Weight Loss Clinic Can Help

At Slim Weight Loss Clinic, we strive to help all our patients work towards a better version of themselves, guiding them to a healthier lifestyle that can stimulate effective weight loss and allow them to maintain a healthy body weight. We’ll be with you during every step of your therapy to make sure your weight loss experience is as comfortable as possible as you work to achieve a leaner physique and improved overall health.

Our friendly and knowledgeable weight-loss specialists will study your unique physiology and accurately tailor effective doses of metformin to fit your specific weight-related condition and help you reach your weight-loss goals.

If you’re ready to work with a team that’s invested in your journey to weight loss, contact us at 1-866-755-0594 and schedule a consultation with one of our physicians to learn more about how our metformin treatment options can help you lose your unwanted body fat.

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What Are the Risks With Metformin?

What Are the Risks With Metformin?

In certain cases, patients who suffer from depression may experience suicidal thoughts while taking Liraglutide. The medication may also contain certain ingredients that can cause an allergic reaction in some patients. Since Liraglutide works to inhibit your blood glucose levels, certain patients may experience symptoms of hypoglycemia or low blood sugar as a result of treatment. Patients with thyroid cancer may need to avoid using Liraglutide as the medication can also increase the risk of thyroid tumors.

Women who use Liraglutide as a weight loss treatment should also stop taking the medication while they are pregnant or breastfeeding. Proceeding to use Liraglutide during pregnancy may harm the unborn baby while inside the fetus. The weight loss medication may also pass into breast milk during breastfeeding and adversely affect the newborn. If you believe that you might be pregnant, make sure to consult with your healthcare professional immediately about discontinuing Liraglutide until it’s safe to resume treatment.

It is imperative that you disclose your medical history, any allergies you may have, and medications or other products that you take with your physician before starting Liraglutide treatment. Armed with that information, your doctor will more than likely continue to monitor your blood sugar levels and will adjust your medication regimen if needed. If you’re a patient with a pre-existing condition that can become seriously affected by Liraglutide, your physician may recommend that you avoid using the treatment and instead offer other alternatives, such as Semaglutide, to help you achieve weight loss.

Other Risks From Taking Metformin

B12 Deficiency

Taking metformin may also decrease the amount of vitamin B12 that your body absorbs from food, eventually causing B12 deficiency. The condition can lower your blood cell count and cause you to experience anemia, which can cause various symptoms such as fatigue, pale skin, and muscle weakness. There’s also an increased risk of developing a B12 deficiency while taking metformin if you are older, have had gastrointestinal surgery, struggle with previous stomach conditions that affect B12 absorption, or if you refrain from consuming animal products due to a vegan or vegetarian diet. It is essential to talk to your doctor about the risks of taking metformin if these conditions apply to you so that they can determine the best approach for your metformin treatment. Talk to your doctor about B12 injections like cyanocobalamin and hydroxocobalamin to mitigate this issue.

 

Lactic Acidosis

One other serious medical complication caused by metformin is lactic acidosis–a condition in which the lactate or lactic acid produced by your muscles accumulates in your blood. This can occur due to increased lactic acid production or your body’s inability to clear the lactic acid from the liver, kidney, or both. Lactic acidosis can also cause you to have cold skin or breathing difficulties, which can appear suddenly or gradually over several days, so make sure to monitor your symptoms and notify your doctor if you begin to experience these side effects.

In many cases, lactic acidosis rarely occurs from taking metformin. But in certain instances, adults may be at increased risk for developing the condition if they struggle with other issues such as:

  • Liver disease
  • Reduced kidney function
  • Heart failure
  • Excessive alcohol consumption

You may also need to temporarily discontinue metformin if you’re preparing to have any type of X-ray, CT scan, or surgery that uses dye, as the contrast used in these procedures can also increase the risk of lactic acidosis. Inform your physician if you have a past history of lactic acidosis, as metformin may not work as a suitable option for you. Your doctor will likely recommend other alternative treatments to help you lose weight.

 

Unexpected Pregnancy

Metformin may also stimulate ovulation in premenopausal women and lead to unintended pregnancy, so discuss the potential risks with your physician if you do not have plans on becoming pregnant.

Even if it turns out that you are indeed pregnant, metformin is usually safe for use during pregnancy and even combined with insulin for pregnant women with type 2 diabetes. However, some pregnant women who take metformin may experience an increase in the severity of mild side effects such as heartburn, diarrhea, nausea, vomiting, and other gastrointestinal changes during pregnancy.

 

Pre-existing Health Conditions

Unfortunately, certain patients may also need to avoid metformin altogether if they already struggle with more serious health complications. Your physician may not recommend metformin, if you suffer from pre-existing conditions such as:

  • Metabolic acidosis
  • Diabetic ketoacidosis
  • Kidney disease
  • Liver disease
  • Heart disease or congestive heart failure

Make sure to disclose any pre-existing health issues with your healthcare provider before considering metformin treatment. They can determine whether or not metformin can exacerbate your current health condition and recommend other weight-loss treatments that may be more suitable to your circumstances.

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